SINGAPORE — Stocks in Asia declined in Tuesday trade as major indexes on Wall Street saw fresh closing highs overnight.

The Hang Seng index in Hong Kong led losses among the region’s major markets, falling more than 2% by the afternoon.

Mainland Chinese stocks were also lower, with the Shanghai composite down 1.2% while the Shenzhen component dipping 1.931%.

South Korea’s Kospi dropped about 2%.

In Japan, the Nikkei 225 slipped 0.95% while the Topix index was 0.7% lower.

Minutes from the Bank of Japan’s December monetary policy meeting showed members agreeing that the central bank would “not hesitate to take additional easing measures if necessary” as it monitors the impact of Covid-19.

“Based on this, most members shared the view that, as for policy rates, it would expect short- and long-term interest rates to remain at their present or lower levels,” the minutes said.

MSCI’s broadest index of Asia-Pacific shares outside Japan fell 1.65%.

Markets in Australia and India are closed on Tuesday for holidays.

Shares of Apple suppliers in Asia were mixed in Tuesday trade after the Cupertino-based tech giant’s stock stateside rose to an all-time high on Monday.

In Japan, Taiyo Yuden shares gained 1.82% while Murata Manufacturing advanced 1.32%. In Taiwan, shares of Hon Hai Precision Industry — better known as Foxconn — fell 1.63% while Taiwan Semiconductor Manufacturing Company dropped 2.69%. LG Display’s stock in South Korea edged 0.21% higher.

On the coronavirus front, Moderna said Monday it’s accelerating work on a Covid-19 booster shot for the recently discovered variant in South Africa. The firm’s researchers said its current coronavirus vaccine appears to work against the two highly transmissible strains found in the U.K. and South Africa, though it looks like it may be less effective against the latter.

Overnight on Wall Street, the S&P 500 rose 0.4% to a new record close of 3,855.36. The Nasdaq Composite also reached a fresh closing high, advancing 0.7% to 13,635.99. The Dow Jones Industrial Average lagged as it dipped 36.98 points to end its trading day at 30,960.

The U.S. dollar index, which tracks the greenback against a basket of its peers, was at 90.381 after seeing levels below 90.3 earlier.

The Japanese yen traded at 103.72 per dollar, weaker than levels below 103.5 against the greenback seen last week. The Australian dollar changed hands at $0.7694, weaker than levels above $0.772 seen yesterday.

Oil prices were lower in the afternoon of Asia trading hours. International benchmark Brent crude futures declined about 0.5% to $55.59 per barrel. U.S. crude futures shed 0.49% to $52.51 per barrel.

— CNBC’s Berkeley Lovelace Jr. contributed to this report.