SINGAPORE — Stocks in Asia-Pacific were mixed on Friday as coronavirus cases continue to surge in the U.S., dimming optimism from positive vaccine news.

Mainland Chinese stocks saw losses by their close. The Shanghai composite declined 0.86% to around 3,310.10 while the Shenzhen component dipped 0.272% to about 13,754.55.

Hong Kong’s Hang Seng index shed 0.43%, as of its final hour of trading. Shares of Chinese tech juggernaut Tencent bucked the trend, and surged 3.29% in Hong Kong. That came after the company announced Thursday its quarterly profit rose more than 80% from last year.

In Japan, the Nikkei 225 shed 0.53% to close at 25,385.87 while the Topix index fell 1.33% to end its trading day at 1,703.22.

South Korea’s Kospi, on the other hand, added 0.74% to close at 2,493.87. The Taiex in Taiwan also rose 0.39% on the day to 13,273.33.

Meanwhile, shares in Australia declined, with the S&P/ASX 200 down 0.2% to close at 6,405.20.

MSCI’s broadest index of Asia-Pacific shares outside Japan rose 0.18%.

Investor focus on Friday was likely on the coronavirus situation in the U.S., as daily new cases of the virus continue to rise in the country, setting fresh records.

U.S. Federal Reserve Chairman Jerome Powell warned Thursday that the “next few months could be challenging” despite recent developments on the vaccine front.

“From our standpoint, it’s just too soon to assess with any confidence the implications of the news for the path of the economy, especially in the near term,” Powell said regarding the vaccine.

Oil prices were lower in the afternoon of Asia trading hours, with international benchmark Brent crude futures down 1.42% to $42.91 per barrel. U.S. crude futures fell 1.82% to $40.37 per barrel.

The U.S. dollar index, which tracks the greenback against a basket of its peers, was last at 92.937 following its rise this week from levels below 92.8.

The Japanese yen traded at 105.01 per dollar, having weakened steeply from levels below 104.3 against the greenback earlier in the trading week. The Australian dollar changed hands at $0.723 after seeing an earlier low of $0.7219.

— CNBC’s Fred Imbert contributed to this report.